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 Synstar Japan Co., Ltd.
          
   
    Technology
        
  
The SSJ Research & Development team, supported by JST, discovered that a certain photosensitizing dye, developed in the field of photography, can kill infectious protozoa that cause certain diseases, and has been able to find highly-promising compounds through repeated cycles of molecular design and synthesis.
  Chloroquine analogue compounds such as Mefloquine and Primaquine, and cyclic peroxy compounds such as Artemisinin are effective against malaria parasites with tolerance to Chloroquine. In particular Artemisinin, which has a trioxa structure and is isolated from the plant Artemisia of the Asteraceae family, has been used as a therapeutic drug.
However, malaria parasites with tolerance to Artemisinin have already emerged, there is therefore the ongoing problem that malaria parasites with tolerance to new antimalarial drugs progressively emerge.
 
The compounds currently under development by SSJ are nitrogen-containing heterocyclic compounds with higher activity than existing drugs at the animal trial stage and that utilize a different mechanism of action.
The compounds are highly effective against the particularly troublesome Chloroquine-resistant parasites.
   
  There are also few drugs that are effective against the serious diseases of African tripanosomiasis, transmitted by tsetse flies (causing the deaths of apploximately 300,000 people every year), Chagas Disease, tranmitted by assassin bugs (affecting apploximately 18 million individuals), and Leishmaniasis, transmitted by sand flies (affecting approximately 12 million individuals). SSJ has also found promising compounds against these protozoans.
 While progressing with optimization of these derivatives, SSJ is also investigating development of formulations of these drugs using nano-dispersion technology, in order to improve drug suitability in oral administration.